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Research shows KPV carries most of α-MSH’s anti-inflammatory activity while acting through its own route, likely by inhibiting IL-1β signaling and bypassing the melanocortin receptors, according to a study of the α-MSH tripeptide in PubMed

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GHK-Cu stimulates angiogenesis primarily through upregulation of key growth factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF/FGF-2), with research demonstrating that GHK-Cu at nanomolar concentrations increases VEGF expression in dermal fibroblasts and stimulates human umbilical vein endothelial cell (HUVEC) proliferation through enhanced VEGF and FGF-2 expression