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Fe loading of MF in vitro reduces the percentage of M1 cells expressing costimulatory molecules CD86 and MHC-II, prevents lipopolysaccharide-induced pro-inflammatory response by reducing nuclear translocation of NF-κB p65 with reduced expression of, IL-1β, IL-6, IL-12 and TNF-α (95)

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Acknowledgements We would like to thank the National Research Foundation of South Africa (NRF) for providing funding for this research, Grant numbers: 76194 and 88062 granted to Prof Emmanuel Mukwevho