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Evidence supports that IL-6 has an ability to suppress the enzymes iodothyronine deiodinases type I (D1) and II (D2), reducing the conversion of prohormone thyroxine T4 to its active form T3, which ensures the deregulation of glutamate cysteine ligase (GCL) and the successive reduction of GSH synthesis [72,73]

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However, based on the information available at this time, we do not believe there is a reasonable basis for us to assume that there will be a meaningful difference in the number of COVID-19 cases treated at IPPS hospitals and LTCHs in FY 2024 relative to FY 2022, such that modifications to our usual ratesetting methodologies would be warranted