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Another, published in 2016, looked at 38 runners to see whether the supplement improved their performance, or reduced a measure of oxidative stress, over a period of 90 days, and found that it did neither

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These investigations also suggest that the role of homocysteine might be overcome by other risk factors (eg, hypertension, diabetes, and dyslipidemia) and/or by various protective mechanisms (such as antioxidant intakes and intrinsic antioxidant systems)