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GLP-1 and GIP are incretin hormones that have been shown to influence insulin secretion, appetite, and glycemic control, while GCG primarily stimulates lipolysis, increases energy expenditure, and promotes fatty acid oxidation

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According to the other classification, based on their morphological features, BCs are divided into three groups: mostly multipolar large BCs (LBCs), expressing PV, neuropeptide Y (NPY), and calbindin (CB) and are capable of inhibiting the neurons in neighboring columns and in upper and lower layers due to the expansive axonal arborization