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For liver-focused supplementation, look for combinations that include: Glutathione itself (250–500 mg) NAC (600–1,200 mg) to support endogenous synthesis Milk thistle (silymarin) for its hepatoprotective properties Selenium as a cofactor for glutathione peroxidase Alpha-lipoic acid to regenerate glutathione Studies on NAC, milk thistle, and selenium combinations have shown improvements in liver enzyme markers in certain populations