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Moreover, in animal models, the lack of IRP2 has been linked to neurodegeneration, underscoring its critical function in neuronal iron homeostasis ( 2.2.5 Iron entry via divalent metal transporter 1 (DMT1) DMT1 is a transmembrane protein that transports divalent metal ions, such as Fe 2+ , from the exterior of the cell into the cytoplasm ( Low oxygen levels, inflammation, and iron levels have a big effect on how much DMT1 is made