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167 Regarding the link between translation initiation and autism, FMRP interacts with cytoplasmic FMRP-interacting protein 1 (CYFIP1), which binds to the cap-binding protein eukaryotic initiation factor 4E (eIF4E) to form a protein complex that inhibits mRNA translation initiation and acts on the RAS-ERK pathway

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As the brain becomes less able to control muscle movements, patients experience worsening muscle weakness and other symptoms such as difficulty breathing, speaking, and swallowing