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For AIDs such as primary immune thrombocytopenia (ITP), sirolimus elicits suppressive immunomodulatory actions by augmenting the Treg cell proportion within the helper T lymphocyte subset, bolstering the count of naive T cells, triggering apoptosis in memory T cells, diminishing effector T cells, and enhancing megakaryocyte differentiation to expedite platelet production (228, 229)

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