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falciparum DHFR mutations result in complete resistance [9, 14], and Pyrimethamine derivatives have been shown to regain activity against some of these DHFR mutants [65]

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The United Kingdom National Quality Assessment Scheme for Haematinic Assays warns against false B12 results and the risk of neurological damage: In the event of any discordance between clinical findings of B12 deficiency and a normal B12 laboratory result, then treatment should not be delayed