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The MTHFR gene provides instructions for making the MTHFR enzyme (methylenetetrahydrofolate reductase) that helps convert folate (vitamin B9) into its active form: L-methylfolate.* This active folate is the key ingredient in producing methyl groups—tiny chemical tags that your body uses in dozens of reactions, including: DNA repair, neurotransmitter synthesis, hormone metabolism, cardiovascular support, and detoxification.* The whole process is called methylation, and without enough methyl groups, your body’s cellular cleanup crews start falling behind on their tasks.* Detox Pathways That Depend on Methylation Methylation affects detox in two major ways: Breaking Down Hormones Estrogen, for example, requires methylation for efficient breakdown and elimination