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Although there have not been definitive studies demonstrating the same role for adiponectin in the non-pregnant state, animal studies have shown that adiponectin secretion is significantly suppressed by prolactin in mice in vivo and in human adipose tissue in vitro (70)
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In this sense, a parallel randomized controlled trial also demonstrated that an isocaloric MedDiet in obese and overweight patients led to an increase in SCFA levels, Faecalibacterium strains (linked to butyrate metabolism) and in gene bacterial gene richness, diminishing Ruminococcus gnavus (with potentially proinflammatory properties) and decreasing systemic inflammation [285]
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