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According to a randomized, double-blind, placebo-controlled trial published in Arthritis & Rheumatism, researchers evaluated N-acetylcysteine (NAC) in patients with systemic lupus erythematosus (SLE). Participants received either placebo or NAC at doses of

doi: 10.1080/09637486.2020.1715353 318 MoustafaIConnollyCAnisMMustafaHOosthuizenFViljoenM

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EAAC1 gene expression is promoted by nuclear factor erythroid 2-related factor 2 (Nrf2) [64], regulatory factor X1 (RFX1) [65], and all-trans-retinoic acid (ATRA) [66], while miR-96-5p, which is one of the microRNAs (miRNAs), has a target sequence in the 3’-UTR of EAAC1 and suppresses the protein expression of EAAC1 posttranslationally, leading to decreased GSH levels in the brain [67,68] (Figure 3)