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Mice expressing dominant-negative N-cadherin develop phenotype similar to IBD This study possibly provided the first experimental in vivo evidence that manipulating mucosal epithelial cell-to-cell adhesion can modulate mucosal barrier properties and that it promotes inflammation

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The typical gradient was 10% to 40% component B over 30 minutes at a flow rate of 1 ml/min at 37°C where component A was 80 mM triethy amine phosphate, pH 3.0 and component B was acetonitrile (ACN)

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