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These effects were more noticeable in longer trials and when ALA was combined with dietary changes.29 A 2020 dose-response meta-analysis confirmed small but statistically significant reductions in weight and BMI across 18+ randomized controlled trials.30 However, waist circumference (WC) — a marker of central obesity — showed no consistent change, and the benefit appeared greater in women and with longer treatment durations

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[2] Harold Bache brought in new partners and fresh capital, [3] and in 1965 incorporated the firm [3] as Bache & Co, Inc., [2] which by his death had expanded to 124 offices worldwide and nearly 6,000 employees