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(45) found decreased monoamine metabolites (phenylacetate, 4-hydroxyphenylacetate) and ACs (C3:0, iso C4:0, iso C5:0, 2-methyl C4:0) in plasma distinguished depressed subjects from controls in HIV-positive and HIV-negative cohorts, and these alterations were correlated with the severity of depression

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However, extracellular Trx provides protective effects against TNF- and ROS-induced apoptosis [88,89]

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