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Milk Thistle Side Effects And Safety Common Side Effects Milk thistle appears to be well-tolerated but can cause mild digestive symptoms, such as: Bloating, fullness, gas, or stomach pain Heartburn Nausea Changes in bowel habits Diarrhea Rare Side Effects Stop taking milk thistle and seek emergency medical care if you develop signs and symptoms of allergic reactions: Skin reactions (rash, hives, itching, eczema) Severe allergic reaction (anaphylaxis), including throat tightening, swelling, and difficulty breathing Warning: The risk of an allergic reaction to milk thistle is higher in people who are allergic to related plants such as ragweed, marigold, daisy, and chrysanthemum