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Loss of SLC33A1 leads to GSSG accumulation and a hyperoxidizing ER environment, which impairs non-native disulfide resolution and causes misfolded protein accumulation

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doi: 10.3390/molecules23071568, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 60

It favors its accumulation in the regions of high electron flux in cells where reactive species are generated.