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Among the studies included in this systematic review, ten directly and one indirectly evaluated the effects of pharmacological interventions modulating this signaling pathway

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Stephen De Felice, founder of the Foundation for Innovation in Medicine, introduced the term “nutraceutical”- a portmanteau of “nutrition” and “pharmaceutical.” He defined nutraceuticals as “a food or part of a food that provides medical or health benefits, including the prevention and/or treatment of disease” (24)